منابع مشابه
Interaction of Staphylococcus aureus persister cells with the host when in a persister state and following awakening
Persister cells, a tolerant cell sub-population, are commonly associated with chronic and recurrent infections. However, little is known about their ability to actually initiate or establish an infection, become virulent and cause pathogenicity within a host. Here we investigated whether Staphylococcus aureus persister cells initiate an infection and are recognized by macrophages, while in a pe...
متن کاملPersistent Persister Misperceptions
Persister cells survive antibiotic treatment due to their lack of metabolism, rather than through genetic change, as shown via four seminal experiments conducted by the discoverers of the phenotype (Hobby et al., 1942; Bigger, 1944). Unfortunately, over seven decades of persister cell research, the literature has been populated by misperceptions that do not withstand scrutiny. This opinion piec...
متن کاملCombatting bacterial persister cells.
Most bacterial cells lead lives of quiet desperation in biofilms, combatting stress; yet, their prevalence attests to their ability to alter gene regulation to cope with myriad insults. Since biofilm bacteria are faced with starvation and other environmental stress (e.g., antibiotics from competitors, oxidative stress from host immune systems), it behooves them to be able to ramp down their met...
متن کاملListen (Awakening)
For the ICAD conference 2004 in Sydney a sonification of ECG and other data was carried out to merge the boundaries between artistic sonification and scientific auditory display. Listen (Awakening) attempts to create in sound the activity of the brain becoming aware of a piece of music and gradually building in its subconscious reaction and appreciation. Certain constraints were put on the soni...
متن کاملAwakening heterochromatin
Awakening heterochromatin ites in the human genome once thought to be inert structural material are brought to life in response to stress, according to results from Jolly et al. (page 25). These inactive DNA stretches are binding sites for HSF1, a transcription factor that activates individual heat shock genes and accumulates in nuclear granules after heat shock. These granules were, like HSF1,...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2016
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2016.06.025